Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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A novel type of hydrogenation using a catalyst poison: Chemoselective inhibition of the hydrogenolysis for O-benzyl protective group by the addition of a nitrogen-containing base
Hironao Sajiki,Kosaku Hirota +1 more
TL;DR: In this paper, a mild and chemoselective hydrogenation method for a variety of reducible functional groups distinguishing from aliphatic and aromatic benzyl ethers was accomplished by the addition of an appropriate nitrogen-containing base to the Pd/C-catalyzed hydrogenation system.
Journal ArticleDOI
Efficient Synthesis and Cell-Transfection Properties of a New Multivalent Cationic Lipid for Nonviral Gene Delivery
TL;DR: The efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for gene delivery applications and experiments show that these complexes efficiently transfect mammalian cells.
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Structure−Activity Studies of Substituted Quinoxalinones as Multiple-Drug-Resistance Antagonists
TL;DR: The results of this structure-activity study indicate that compounds with carbonyl substitutions of the phenoxy group demonstrate excellent antagonism of Pgp while having relatively low toxicity toward drug-sensitive cells and none of these compounds antagonized MRP1.
Journal ArticleDOI
Azomethine ylide cycloaddition/reductive heterocyclization approach to oxindole alkaloids: asymmetric synthesis of (-)-horsfiline.
TL;DR: The intermolecular [3 + 2] annulation of azomethine ylides with 2(2-nitrophenyl)acrylate dienophiles followed by reductive heterocyclization affords the spiro(indole-pyrrolidine) ring system to accomplish a concise and highly enantioselective synthesis of (-)-horsfiline 1.
Journal ArticleDOI
C-glycoside clustering on calix[4]arene, adamantane, and benzene scaffolds through 1,2,3-triazole linkers.
Alessandro Dondoni,Alberto Marra +1 more
TL;DR: A route has been paved toward the preparation of triazole glycocluster libraries via the copper(I)-catalyzed modern version of the classical Huisgen 1,3-dipolar cycloaddition of azides to alkynes.