Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Analysis of free and esterified sterols in fats and oils by flash chromatography, gas chromatography and electrospray tandem mass spectrometry.
Paavo Kalo,Tiia Kuuranne +1 more
TL;DR: A method for the analysis of free and esterified sterols has been developed and sterol esters and acylglycerols of the free sterol fraction were transesterified to methyl esters.
Journal ArticleDOI
Total synthesis of (+)-ambruticin S
Stephen M. Berberich,Robert J. Cherney,John T. Colucci,Christine Courillon,Leo S. Geraci,Thomas A. Kirkland,Matthew A. Marx,Matthias Schneider,Stephen F. Martin +8 more
TL;DR: A convergent total synthesis of the novel antifungal agent ambruticin S (1) has been completed from the assembly of intermediates 18, 33 and 52 that served as the respective A-, B-, and C-ring precursors.
Journal ArticleDOI
In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge.
TL;DR: The hypothesis that 25-hydroxycholesterol is endogenously produced from cholesterol at early time intervals after an acute dietary cholesterol challenge is supported.
Journal ArticleDOI
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones.
Vanessa Point,K.V.P. Pavan Kumar,Sylvain Marc,Vincent Delorme,Goetz Parsiegla,Sawsan Amara,Frédéric Carrière,Gérard Buono,Frédéric Fotiadu,Stéphane Canaan,Julien Leclaire,Jean-François Cavalier +11 more
TL;DR: The powerful inhibition of PPL, DGL, PLRP2s, hCEH and to a lesser extend HPL, suggests that oxadiazolone derivatives could also provide useful leads for the development of novel and more discriminative inhibitors of digestive lipases.
Journal ArticleDOI
Nitrated fatty acids: synthesis and measurement
TL;DR: Multiple methods for nitrated fatty acid synthesis and sample extraction from complex biological matrices are described and a rigorous method of qualitative and quantitative detection ofNitrated fatty acids by liquid chromatography-mass spectrometry is described.