Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Glycoside-Clustering Round Calixarenes toward the Development of Multivalent Carbohydrate Ligands. Synthesis and Conformational Analysis of Calix[4]arene O- and C-Glycoconjugates
TL;DR: In this paper, a tetra-propoxycalix[4]arene scaffold was used to obtain bis-glycosylated products with a flattened cone arrangement (far conformation).
Journal ArticleDOI
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
Walter A Cristofoli,Leonard I. Wiebe,Erik De Clercq,Graciela Andrei,Robert Snoeck,Jan Balzarini,Edward E. Knaus +6 more
TL;DR: A broad-spectrum viral panel screen showed that these 5-alkynylarabino/deoxy-uridines exhibit moderate anti-HSV-1 activity, with no difference in potency between arabinouridines and 2'-deoxyuridine.
Journal ArticleDOI
Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.
Wayne C. Guida,Robert D. Elliott,H. Jeanette Thomas,John A. Secrist,Y. Sudhakar Babu,Charles E. Bugg,Mark D. Erion,Steven E. Ealick,John A. Montgomery +8 more
TL;DR: The only phosphate mimics that bind like phosphate itself are themselves highly ionic, probably with limited ability to penetrate cell membranes.
Journal ArticleDOI
Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes
Le Li,Seth B. Herzon +1 more
TL;DR: This work describes an approach to emulate the efficiency of natural reaction cascades within a synthetic catalyst by the temporal separation of catalytic activities, allowing for the efficient processing of a substrate through a cascade pathway.
Journal ArticleDOI
A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine
TL;DR: In this article, a range of N,N-dialkylanilines have been successfully converted to the parent substituted benzenes by a novel two-step pathway, and the products are obtained in good yields and optical purity of adjacent stereocenters is maintained.