Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Alkynyliodonium salts in organic synthesis. Development of a unified strategy for the syntheses of (-)-agelastatin A and (-)-agelastatin B.
TL;DR: The total syntheses of natural agelastatin A and agelASTatin B were accomplished via a strategy that utilized an alkynyliodonium salt --> alkylidenecarbene --> cyclopentene transformation to convert a relatively simple amino alcohol derivative to the functionalized core of the agelastsatin system.
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Light-driven depolymerization of native lignin enabled by proton-coupled electron transfer
TL;DR: A catalytic, light-driven method for the redox-neutral depolymerization of native lignin biomass at ambient temperature via a proton-coupled electron-transfer activation of an alcohol O–H bond, which then facilitates the β-scission of a vicinal C–C bond.
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Synthetic studies on arene-olefin cycloadditions. ii. total synthesis of (±)-isocomene
TL;DR: In this paper, the arene-olefin meta-photocycloaddition is shown to provide the basis for an effective and general approach to polyquinane natural products as demonstrated by the synthesis of (±)-isocomene ( 5 ) in five steps based on Z-2bromo-2-butene and 2-bromotoluene.
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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
TL;DR: It is shown that the TMEM97 gene is expressed in mouse and human dorsal root ganglion including populations of neurons that are involved in pain; however, the gene is also likely expressed in non-neuronal cells that may contribute to the observed behavioral effects.
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Bischler-Napieralski Cyclization-N/C-Alkylation Sequences for the Construction of Isoquinoline Alkaloids. Synthesis of Protoberberines and Benzo[c]phenanthridines via C-2'-Functionalized 3-Arylisoquinolines(1).
TL;DR: Efficient synthetic routes to isoquinoline alkaloids of the protoberberine and benzo[c]phenanthridine classes are reported, with key transformations derived from the intramolecular cyclization of C-2'-functionalized N-(1,2-diarylethyl)amides or enamides via 3-arylisoquinoline derivatives.