Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Azatides: Solution and liquid phase syntheses of a new peptidomimetic
Hongna Han,Kim D. Janda +1 more
TL;DR: In this paper, an efficient method has been developed for the solution and liquid phase syntheses of a biopolymer mimetic consisting of α-aza-amino acids linked in a repetitive manner to form what we term an azatide oligomer.
Journal ArticleDOI
Supramolecular polymer chemistry: self-assembling dendrimers using the DDA.AAD (GC-like) hydrogen bonding motif.
TL;DR: Studies using (1)H NMR, size exclusion chromatography (SEC), and dynamic light scattering (DLS) support the cooperative formation of cyclic hexamers in apolar solvents and mixing studies with 2a-c indicate their usefulness in constructing dynamic combinatorial libraries.
Journal ArticleDOI
Charge-transfer-directed radical substitution enables para-selective C–H functionalization
Gregory B. Boursalian,Gregory B. Boursalian,Won Seok Ham,Anthony R. Mazzotti,Tobias Ritter,Tobias Ritter +5 more
TL;DR: It is proposed that radicals with high electron affinity elicit areneto-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity.
Journal ArticleDOI
Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides
TL;DR: The finding that N-alkylphosphoramidate substituents can enhance the binding of certain oligonucleotides to their complementary polyn nucleotides suggests the existence of a novel source of polynucleotide affinity.
Journal ArticleDOI
Total Synthesis and Immunosuppressive Activity of (−)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization
Daniel Romo,Robert M. Rzasa,Helene A. Shea,Kaapjoo Park,Joseph M. Langenhan,Luo Sun,and Alexander Akhiezer,Jun O. Liu +7 more
TL;DR: The asymmetric synthesis of the potent immunosuppressive agent (−)-pateamine A isolated from the marine sponge Mycale sp. is described in this paper, where a key strategy employed in the synthesis was a β-lactam-based macrocyclization to form the 19-membered dilactone macrolide.