Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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A facile and highly efficient route to α-amino phosphonates via three-component reactions catalyzed by Mg(ClO4)2or molecular iodine
TL;DR: Three-component reactions of aldehydes, amines, and diethyl phosphite catalyzed by Mg(ClO4)2 or molecular iodine afforded the corresponding alpha-amino phosphonates in excellent yields under mild reaction conditions.
Journal ArticleDOI
Rhodium-catalyzed reductive cyclization of 1,6-diynes and 1,6-enynes mediated by hydrogen: catalytic C-C bond formation via capture of hydrogenation intermediates.
TL;DR: These transformations represent the first examples of metal-catalyzed reductive carbocyclization mediated by hydrogen and 1,3-diene and alkene containing cyclization products 1b-9b and 10b-18b.
Journal ArticleDOI
A Convenient One-Pot Preparative Method for 4,5-Diarylisoxazoles Involving Amine Exchange Reactions
Esther Domínguez,Estíbaliz Ibeas,Eduardo Martínez de Marigorta,and Jon Kepa Palacios,Raul SanMartin +4 more
TL;DR: In this paper, a ring-opening transformation to β-keto nitriles and 1,3-amino alcohol derivatives is described. But this conversion implies an uncommon amine group exchange reaction.
Journal ArticleDOI
Lipid-binding characteristics of the polybasic carboxy-terminal sequence of K-ras4B.
Rania Leventis,John R. Silvius +1 more
TL;DR: Results suggest that the targeting of the mature K-ras4B carboxy-terminus to the plasma membrane is not mediated by a kinetic-trapping mechanism or by specific binding to particular anionic lipids but may rest on the sensitive surface potential-sensing function of this region of the protein.
Journal ArticleDOI
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site
R. Di Fabio,Anna-Maria Capelli,Nadia Conti,Alfredo Cugola,Daniele Donati,A. Feriani,Paola Gastaldi,Giovanni Gaviraghi,Cheryl T. Hewkin,Fabrizio Micheli,Andrea Missio,Manolo Mugnaini,Angelo Pecunioso,Anna M. Quaglia,E. Ratti,Luciana Rossi,Giovanna Tedesco,David G. Trist,Angelo Reggiani +18 more
TL;DR: Results from synthesizing and evaluating indole-2-carboxylates refining the proposed pharmacophore model of the glycine binding site associated with the NMDA receptor suggest the terminal phenyl ring of the C-3 side chain should lie in a nonhydrophobic pocket of limited size.