Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus
A.P. Treschow,Lynn D. Hodges,Paul F.A. Wright,Paul Wynne,Nicolette Kalafatis,Theodore A. Macrides +5 more
TL;DR: The present study has identified in the marine mollusc, Perna canaliculus, an homologous series of novel omega 3 polyunsaturated fatty acids (ω-3 PUFA) with significant anti-inflammatory (AI) activity.
Journal ArticleDOI
A 2,3‘-Substituted Biphenyl-Based Amino Acid Facilitates the Formation of a Monomeric β-Hairpin-like Structure in Aqueous Solution at Elevated Temperature
TL;DR: An NMR structural evaluation of heptapeptides incorporating 1 revealed the presence of a hydrophobic cluster involving an aromatic ring of 1 and a side chain of one of the flankingHydrophobic α-amino acids, even though the peptides lack sufficient length to adopt a β-sheet structure.
Journal ArticleDOI
Synthesis and pharmacological study of ethyl 1-methyl-5-[2-substituted-4-oxo-3(4H)-quinazolinyl]-1H-pyrazole-4-acetates
Giuseppe Daidone,Benedetta Maggio,Demetrio Raffa,Salvatore Plescia,M. L. Bajardi,A. Caruso,Vmc Cutuli,M. Amico-Roxas +7 more
TL;DR: A number of new ethyl 1-methyl-5-[4-oxo-3(4 H )-quinazolinyl]-1 H -pyrazole-4-acetates substituted at the 2 position of the quinazolinone ring were prepared as mentioned in this paper.
Journal ArticleDOI
First Total Synthesis of ent-Gelsedine via a Novel Iodide-Promoted Allene N-Acyliminium Ion Cyclization
TL;DR: The first total synthesis of the oxindole alkaloid gelsedine starting from (S)-malic acid is described, which leads to the unnatural (+)-enantiomer of gelsingine in 21 steps and 0.10% overall yield.
Patent
Tetracyclic indole derivatives as antiviral agents
TL;DR: In this article, a tetracyclic indole compounds of formula (I) were defined, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.