Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Genetic Control and Evolution of Sesquiterpene Biosynthesis in Lycopersicon esculentum and L. hirsutum
Rutger Van der Hoeven,Antonio J. Monforte,David C Breeden,Steven D. Tanksley,John C. Steffens +4 more
TL;DR: Segregation analysis between Lysopersicon esculentum (cultivated tomato) and L. hirsutum (wild form) in conjunction with positional verification by using near-isogenic lines demonstrated that biosynthesis of two structurally different classes of sesquiterpenes in these species is controlled by loci on two different chromosomes.
Journal ArticleDOI
Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum granulatum: Structure Elucidation and Synthesis†
Roberto G. S. Berlinck,Robert Britton,Edward Piers,Lynette Lim,Michel Roberge,and Rosana Moreira da Rocha,Raymond J. Andersen +6 more
TL;DR: Crude methanol extracts of the ascidian Didemnum granulatum collected in Brazil showed activity in a new screen for G2 cell cycle checkpoint inhibitors, and two candidate structures for the inhibitor have been prepared via a short and efficient biomimetic synthesis.
Journal ArticleDOI
Total Synthesis of Dimethyl Sulfomycinamate
T. Ross Kelly,Fengrui Lang +1 more
TL;DR: The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on doubly activated pyridine 62 and the condensation reaction between bromo ketone 69 and amide 28 to form the oxazole moiety 76.
Journal ArticleDOI
Macrocyclic inhibitors of penicillopepsin. 1. design, synthesis, and evaluation of an inhibitor bridged between p1 and p3
TL;DR: The macrocyclic peptidyl phosphonate 1-L was designed on the basis of the conformation of an acyclic analogue bound to the aspartic protease penicillopepsin, and it appears that the low-energy conformation can be accommodated in the pencillopepepsin active site without significant distortion.
Journal ArticleDOI
Inductive effects on the structure of proline residues
TL;DR: Results indicate that electron-withdrawing substituents in the 4-position of proline residues can have a significant influence on the structure of these residues, and the change in pyramidylization suggests that such substituent increase the sp3-character of the prolyl nitrogen atom and could alter the rate of prolyL peptide bond isomerization.