Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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A Novel Concept for Transition‐Metal‐Catalyzed Reactions: Electron Transfer under Buffered Protic Conditions
TL;DR: In this paper, a novel concept for conducting transition metal-catalyzed radical reactions that allows highly diastereoselective titanocene-catalysed pinacol couplings is described.
Journal ArticleDOI
A novel glycoconjugated N-acetylamino aldehyde hydrazone azo dye as chromogenic probe for cyanide detection in water.
TL;DR: A new selective chemodosimeter probe of cyanide anions in aqueous media was developed by the introduction of a simple glyco-conjugated o-(carboxamido) aldehyde hydrazone into an azo dye that recognizes cyanideAnions among other competing anions through reversible covalent bonding.
Journal ArticleDOI
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA.
TL;DR: It is found that the activity of PARP proteins following exposure to platinum-modified DNA results in the dissociation of DNA-bound proteins, and that NTera2 cells are especially sensitive to PARP inhibition.
Journal ArticleDOI
Diastereoselective Synthesis of Substituted Tetrahydroquinoline-4-carboxylic Esters by a Tandem Reduction−Reductive Amination Reaction
TL;DR: The reaction has been extended to the synthesis of tricyclic structures with similar high diastereoselection to give a methyl (+/-)-1-methyl-2-alkyl-1,2,3,4-tetrahydroquinoline-4-carboxylate.
Journal ArticleDOI
A short synthesis of the parp inhibitor 2-(4-trifluoro-methylphenyl)benzimidazole-4-carboxamide (NU1077)
Steven C. Austen,John M. Kane +1 more
TL;DR: In this article, a four-step synthesis of the PARP inhibitor 2-(4-trifluoromethylphenyl)benzimidazole-4-carboxamide (1, NU1077) is presented.