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Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral α-amino acid bioisostere
William A. Kinney,Magid Abou-Gharbia,Deanna T. Garrison,Jean Schmid,Dianne Kowal,Donna R. Bramlett,Tracy L. Miller,Rene P. Tasse,Margaret M. Zaleska,John A. Moyer +9 more
TL;DR: Compound 15, being a unique NMDA antagonist structural type with a favorable preclinical profile, may offer advantages over existing NMDA antagonists for the treatment of neurological disorders such as stroke and head trauma.
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A novel biotinylated adenylate analogue derived from pyrazolo[3,4-d]pyrimidine for labeling DNA probes.
Charles R. Petrie,A. David Adams,Michael R. Stamm,Jeffery Van Ness,Susan M. Watanabe,Rich B. Meyer +5 more
TL;DR: A novel dATP analogue, 3-[5-[(N-biotinyl-6- amiocaproyl)amino]pentyl]-1-(2-deoxy-beta-D-erythro-pentofuranosyl )-1H-pyrazolo[3,4-d]pyrimidin-4-amine 5'-triphosphate (9, bio-13-dAPPTP), which is modified at the 3-
Journal ArticleDOI
N-Substituted Adenosines as Novel Neuroprotective A1 Agonists with Diminished Hypotensive Effects
Lars J. S. Knutsen,Jesper Lau,Hans Petersen,Christian Thomsen,Jan Weis,Michael Shalmi,Martin Edward Judge,and Anker Jon Hansen,Malcolm J. Sheardown +8 more
TL;DR: It is concluded that two of the novel adenosine derivatives revealed herein, 12 and 5'-deoxy-5'-chloro-N-[4-(phenylthio)-1-piperidinyl]adenosine (NNC 21-0147, 13), representatives of a new series of P(1) ligands, reinforce the fact that novel selective adenosines A(1%) agonists have potential in the treatment of cerebral ischemia in humans.
Journal ArticleDOI
Alkylation of the isoquinoline skeleton in the 1-position
TL;DR: In this article, the nucleophilic reactivity in the l position of 1,2,3,4-tetrahydroisoquinoline is generated by lithiation of the N-pivaloyl- and N-phosphinoyl -derivatives.
Journal ArticleDOI
Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes.
Usha Ghosh,Deshanie Ganessunker,Viswajanani Jitendra Sattigeri,Kathryn E. Carlson,Deborah J Mortensen,Benita S. Katzenellenbogen,John A. Katzenellenbogen +6 more
TL;DR: These novel heterocyclic ligands expand the repertoire of chemical structures that bind to the estrogen receptor and could prove to be useful in elucidating the biological behavior of the two ER subtypes and in forming the basis for new estrogen pharmaceuticals having desirable tissue selectivity.