Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Structure Elucidation of Lolitrem F, a Naturally Occurring Stereoisomer of the Tremorgenic Mycotoxin Lolitrem B, Isolated from Lolium perenne Infected with Acremonium lolii
Sarah C. Munday-Finch,Alistair L. Wilkins,Christopher O. Miles,Richard M. Ede,Ralph A. Thomson +4 more
TL;DR: In this article, a new lolitrem was isolated from endophyte-infected perennial ryegrass and its structure was shown by mass spectrometry and one-and two-dimensional NMR spectroscopy to be a 31,35-cis-fused isomer of Lolitrem B.
Journal ArticleDOI
A facile, multigram synthesis of ribofuranoid glycals
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A General and Stereocontrolled Strategy for the Iterative Assembly of Enantiopure Polypropionate Subunits: Synthesis of the C19−C28 Segment of Rifamycin S from a Single Chiron
TL;DR: In this article, a simple method for the stereocontrolled construction of polypropionate stereotriads in high enantio- and diastereomeric purities is presented.
Journal ArticleDOI
Synthesis of Enantiomerically Pure D‐ and L‐(Heteroaryl)alanines by asymmetric hydrogenation of (Z)‐α‐amino‐αβ‐didehydro esters
TL;DR: In this paper, a wide range of methyl and tert-butyl (Z)-2-(acylamino)-3-(heteroaryl)acrylates catalyzed by diphosphinerhodium catalysts was studied for the synthesis of enantiomerically pure 3-furyl-, 3-thienyl-, and 3-pyrrolylalanines (see 3a-f, and 4a-d, g; Scheme 1).
Journal ArticleDOI
Cyclic aza-peptide integrin ligand synthesis and biological activity.
Jochen Spiegel,Jochen Spiegel,Carlos Mas-Moruno,Horst Kessler,Horst Kessler,William D. Lubell +5 more
TL;DR: A general approach for the synthesis of cyclic aza-peptides was developed by modification of strategies for linear aza -peptide synthesis and applied in the preparation of cyclo-pentapeptides containing the RGD (Arg-Gly-Asp) sequence.