Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Synthesis of 2-(p-thiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid: Application of the 4-methoxy-2,3,6-trimethylbenzenesulfonamide protecting group in the synthesis of macrocyclic polyamines
TL;DR: A modest improvement in overall percent conversion of (p-nitrobenzyl)ethylenediamine into substituted macrocyclic polyamine was observed when comparing the Mtr vs Ts protection, and showed the following order of relative stability: I < VII << VI << IV < V Approximately equal to II approximately equal to III.
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Synthesis of trisubstituted furans from epoxypropargyl esters by sequential SmI2-promoted reduction-elimination and Pd(II)-catalyzed cycloisomerization.
TL;DR: A two-step one-pot synthesis of 2,3,5-trisubstituted furans 8 from 4, 5-epoxyalk-2-ynyl esters 6 is described, which offers the possibility of introducing branched substituents at C-5 of the furan ring.
Journal ArticleDOI
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.
Simon Haydar,Chiara Ghiron,Laura Bettinetti,Hendrick Bothmann,Thomas A. Comery,John Dunlop,Salvatore La Rosa,Iolanda Micco,Martina Pollastrini,Joanna Quinn,Renza Roncarati,Carla Scali,Michela Valacchi,Maurizio Varrone,Riccardo Zanaletti +14 more
TL;DR: This compound is a selective agonist of the alpha(7) nAChR with excellent in vitro and in vivo profiles, excellent brain penetration and oral bioavailability, and demonstrates in vivo efficacy in multiple behavioural cognition models.
Journal ArticleDOI
Tritylketone und tritylenone. Beiträge zur sterisch erzwungenen Michael-Addition und zur diastereoselektiven Aldol-Addition
TL;DR: Tritylketones and tritylenones as mentioned in this paper are two types of derivatives of trityllithium and aldehydes that can be added to (CH3)3Al-mediated aldol with subsequent dehydration.