Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Connecting remote C-H bond functionalization and decarboxylative coupling using simple amines.
Francisco de Azambuja,Francisco de Azambuja,Ming-Hsiu Yang,Ming-Hsiu Yang,Taisiia Feoktistova,Manikandan Selvaraju,Alexander C. Brueckner,Markas A. Grove,Suvajit Koley,Paul Ha-Yeon Cheong,Ryan A. Altman +10 more
TL;DR: A catalytic para -selective alkylation reaction connects C–H functionalization and decarboxylative coupling strategies using simple bases to trap a previously hidden intermediate and exploits an ‘inverted sequence’ that forms the C–C bond prior to C-H bond cleavage and provides a new entry into C–h functionalization reactions.
Journal ArticleDOI
Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols
Steven P. Tanis,Bruce Roy Evans,James A. Nieman,Timothy Parker,Taylor Wendy Dianne,Steven E. Heasley,Paul M. Herrinton,Perrault William R,Richard A. Hohler,Lester A. Dolak,Matthew R. Hester,Eric P. Seest +11 more
TL;DR: In this article, the authors describe the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-yl-2methylaminoethanol.
Journal ArticleDOI
Synthesis of Bicyclic Enediynes from Bis[phenyl[(trifluoromethanesulfonyl)oxy]iodo]acetylene: A Tandem Diels-Alder/Palladium(II)- and Copper(I)-Cocatalyzed Cross-Coupling Approach.
John H. Ryan,Peter J. Stang +1 more
TL;DR: The reaction of bicycloalkenylbis(phenyliodonium) triflates 1a or b with alkynylstannanes 2a-g proceeds smoothly and with selectivity to afford good to excellent yields of bicyclic enediynes 3a-k.
Journal ArticleDOI
Diversity oriented syntheses of fused pyrimidines designed as potential antifolates
Colin L. Gibson,Judith K. Huggan,Alan R. Kennedy,Lionel Kiefer,Jeong Hwan Lee,Colin J. Suckling,Carol Clements,Alan L. Harvey,William N. Hunter,Lindsay B. Tulloch +9 more
TL;DR: Significant structural features required for inhibition of this important drug target enzyme have been identified and several compounds were found to inhibit pteridine reductases from the protozoan parasites Trypanosoma brucei and Leishmania major at the micromolar level.
Journal ArticleDOI
Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine.
TL;DR: The preparation of dibenzocycloheptyne-Co(2)(CO)(6) complexes by intramolecular Nicholas reactions of biaryl-2-propargyl alcohol-Co(-CO)( 6) derivatives is described and individual members of which have been employed in a formal total synthesis of (-)-allocolchicine.