Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Scale esterase: A pheromone-degrading enzyme from scales of silk mothAntheraea polyphemus.
TL;DR: Body scales of the silk mothAntheraea polyphemus contain an esterase which can degrade the female sex pheromone of this species, and may play a significant role in the behaviors associated with sex-pheromone attraction.
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Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.
David Alagille,Ronald M. Baldwin,Bryan L. Roth,Jarda T. Wroblewski,Ewa Grajkowska,Gilles Tamagnan,Gilles Tamagnan +6 more
TL;DR: The results pointed out the critical role of the para position of the two aromatic rings, which leads to inactive products and permitted the discovery of potent mGluR5 antagonists.
Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N, N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels
Michel Maillard,Michael E. Perlman,Oved Amitay,Deborah Baxter,David Berlove,Sonia Connaughton,James B. Fischer,Jun Qing Guo,Lain-Yen Hu,Robert N. McBurney,Peter I. Nagy,Katragadda Subbarao,Elizabeth Yost,Lu Zhang,Graham J. Durant +14 more
TL;DR: The retention of significant neuronal Na+ blockade in all types of semirigid conformers gives evidence for a multiple mode of binding in this class of compounds and can possibly be attributed to a poor structural specificity of the site(s) of action.
Journal ArticleDOI
Fragmentation of 6-deoxy-6-halo-hexono-1,5-ortholactones: a concerted, nonstereospecific process
Bruno Bernet,Andrea Vasella +1 more
TL;DR: The synthesis of the D-arabino and D-ribo-ortholactones 13a-f and 15b-f was described in this paper, where the results were only compatible with a concerted, nonsynchronous process, where both the axial lone pair of the ring oxygen atom and the lone pair formed during rupture of the C(5), O-bond participated in the elimination of the equatorial C(1)-alkoxy groups, respectively.
Journal ArticleDOI
Digestive lipases: inactivation by phosphonates.
TL;DR: Phosphonates mimicking the transition state which occurs during carboxyester hydrolysis were synthesized and investigated as potential inactivators of human pancreatic and gastric lipases and found to be more sensitive than HPL towards these phosphonates.