Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies
TL;DR: This protocol describes the methodology for the synthesis of dehydroalanine (Dha)-containing peptides and illustrates their use in convergent ligation strategies for the preparation of peptide conjugates.
Journal ArticleDOI
Factors influencing the extent and regiospecificity of cross-link formation between single-stranded DNA and reactive complementary oligodeoxynucleotides.
TL;DR: Cross-link formation, within the duplex, by oligodeoxynucleotides containing a 5-[omega-(omega-haloacylamido)alkyl]-2'-deoxyuridine to a complementary oligode oxynucleotide was investigated under conditions approximating the physiologic environment.
Patent
Synthetic process for the manufacture of an ecteinaschidin compound
Andrés Francesch,Carolina Fernandez,Jose Luis Chicharro,Pilar Gallego,Zarzuelo Maria,Ignacio Manzanares,Marta Pérez,Carmen Cuevas,María Jes{dot over }s Martin,Simon Munt +9 more
TL;DR: In this article, the process involving forming a 1,4 bridge using a l-labile, 10-hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound was described.
Journal ArticleDOI
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents.
Alessia Catalano,Alessia Carocci,Filomena Corbo,Carlo Franchini,Marilena Muraglia,Antonio Scilimati,Michela De Bellis,Annamaria De Luca,Diana Conte Camerino,Maria Stefania Sinicropi,Vincenzo Tortorella +10 more
TL;DR: Two conformationally restricted analogues of tocainide, designed and synthesized as voltage-gated skeletal muscle sodium channel blockers, showed a marked increase in both potency and use-dependent block.
Journal ArticleDOI
Low-calorie triglyceride synthesis by lipase-catalyzed esterification of monoglycerides
G. P. McNeill,P. E. Sonnet +1 more
TL;DR: The fatty acid-specific lipase from Geotrichum candidum promoted minimal transesterification of erucic acid and resulted in a yield of 75% caprucin and approximately 10% interesterification products, thereby converting capricin into caprenin, a commercially available low-calorie triglyceride.