Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Macrocyclic compounds as antiviral agents
Benedetta Crescenzi,Monica Donghi,Marco Ferrara,Cristina Gardelli,Steven Harper,Uwe Koch,Michael Rowley,Vincenzo Summa +7 more
TL;DR: The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R1, Ra, Rb, R3, R4, M, Z, ring A and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus as discussed by the authors.
Journal ArticleDOI
Chiral, non-racemic α-hydroxyphosphonates and phosphonic acids via stereoselective hydroxylation of diallyl benzylphosphonates
TL;DR: The enantiomeric purity and absolute configuration of α-hydroxyphosphonates were established from 1 H and 31 P NMR spectroscopy of the (S )- O -methylmandelate esters as discussed by the authors.
Journal ArticleDOI
Evidence for the presence of 7-hydroperoxycholest-5-en-3β-ol in oxidized human LDL
Bruno Malavasi,M.F. Rasetti,P. Roma,Roberta Fogliatto,Pietro Allevi,Alberico L. Catapano,Giovanni Galli +6 more
TL;DR: Analysis of the components by thin layer chromatography and mass spectrometry allowed to establish that 7 alpha- and 7 beta-hydroperoxycholest-5-en-3 beta-ol (7 alpha OOH and beta OOH) are largely prevalent among the oxysterols at early times of oxidation.
Journal ArticleDOI
A new stereoselective synthesis of chiral γ-functionalized (E)-allylic amines
TL;DR: Chiral t -Boc protected propargylic amines have been obtained starting from aminoaldehydes derived from natural aminoacids as discussed by the authors, which are useful intermediates for the synthesis of the corresponding γ-funtionalized allylic systems.
Journal ArticleDOI
Fischer Carbene Complexes in Heterocyclic Synthesis. Selective Cycloaddition Reactions to 2-Aza-1,3-butadienes
TL;DR: In this paper, a set of Fischer carbene complexes are reacted with substituted 3-trimethylsilyl)oxy]-2-aza-1,3-butadienes, yielding 5- to 7-membered nitrogen-containing heterocycles in a selective manner.