Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
A chemoenzymatic total synthesis of (+)-clividine.
TL;DR: A key feature associated with the closing stages of the synthesis involved the diastereoselective addition of a nitrogen-centered radical onto a pendant cyclohexene to establish the cis-fused D-ring and the required stereochemistry at C11b in the final product ent-1.
Journal ArticleDOI
In vitro leishmanicidal and cytotoxic activities of the glycoalkaloids from Solanum lycocarpum (Solanaceae) fruits.
Mariza Abreu Miranda,Renata Fabiane Jorge Tiossi,Mariana Rosa da Silva,Kelly Cristina Rodrigues,Christian Collins Kuehn,Luiz Gustavo Rodrigues Oliveira,Sérgio de Albuquerque,James D. McChesney,Claudio M. Lezama-Davila,Angelica Patricia Isaac-Marquez,Jairo Kenupp Bastos +10 more
TL;DR: In vitro leishmanicidal activity on promastigote forms of Leishmania amazonensis and cytotoxicity, using LLCMK2 cells, of the glycoalkaloids from the fruits of Solanum lycocarpum, determined by colorimetric methods are reported.
Journal ArticleDOI
Reactions of Cobalt-Complexed Acetylenic Aldehydes with Chiral (γ-Alkoxyallyl)boranes: Enantioselective Synthesis of 3,4-Dioxy 1,5-Enynes and Stereoselective Entry to Polyfunctional Building Blocks
P. Ganesh,Kenneth M. Nicholas +1 more
TL;DR: In this paper, the enantioselective routes to polyfunctional building blocks using Co-based technology were investigated for diastereo and enanti-selective polyfunctional reactions.
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Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore
Cheng Yu Lee,Yun Chung Chen,Hao Chun Lin,Yuandong Jhong,Chih Wei Chang,Ching Hua Tsai,Chai-Lin Kao,Tun Cheng Chien +7 more
TL;DR: A facile and effective synthesis for a wide variety of 4-arylidene-5-imidazolinone derivatives was developed by Erlenmeyer azlactone synthesis from N -acylglycines and arylaldehydes as discussed by the authors.
Journal ArticleDOI
The pentafluorosulfanyl group in cannabinoid receptor ligands: synthesis and comparison with trifluoromethyl and tert-butyl analogues
TL;DR: In this paper, an array of cannabinoid ligands, bearing meta-and para-substituted pentafluorosulfanyl (SF5) aniline groups in position 3 of the pyrazole ring, was efficiently synthesized and compared with the exact trifluoromethyl and tert-butyl analogues.