Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Donn G. Wishka,Daniel P. Walker,Karen M. Yates,Steven Charles Reitz,Jia S,Jason K. Myers,Olson Kl,Eric Jon Jacobsen,Mark L. Wolfe,Vincent E. Groppi,Hanchar Aj,Bruce A. Thornburgh,Luz A. Cortes-Burgos,Erik H. F. Wong,Brian A. Staton,Thomas J. Raub,Nicole R. Higdon,Theron M. Wall,Raymond S. Hurst,Rodney R. Walters,William E. Hoffmann,Mihály Hajós,Franklin S,Carey G,Gold Lh,Karen K. Cook,Steven B. Sands,Sabrina X. Zhao,Soglia,Amit S. Kalgutkar,Arneric Sp,Bruce N. Rogers +31 more
TL;DR: Compound 14 is a potent and selective alpha7 nAChR agonist with an excellent in vitro profile and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.
Journal ArticleDOI
On the Mechanisms of Enantioselective Reactions Using α,α,α′,α′ -Tetraaryl-1,3-dioxolane-4,5-dimethanol(TADDOL)-Derived Titanates: Differences between C2- and C1-symmetrical TADDOLs – facts, implications and generalizations†
TL;DR: In this article, it was shown that a single chiral titanate is involved in the product-forming step, and that the bulky TADDOLate ligand renders the Ti-center catalytically more active than that of (i-PrO)4Ti, due to fast dynamics of ligand exchange on the sterically hindered Ti center.
Journal ArticleDOI
The direct anti-Markovnikov addition of mineral acids to styrenes
TL;DR: It is demonstrated how nucleophilic addition reactions mediated by photoredox catalysis can change the way electrophilic and homofugal precursors are constructed.
Journal ArticleDOI
In vitro cytotoxicity evaluation of some substituted isatin derivatives.
Kara L. Vine,Julie M. Locke,Marie Ranson,Kirsten Benkendorff,Stephen G. Pyne,John B. Bremner +5 more
TL;DR: Results indicate that di- and tri-substituted isatins may be useful leads for anticancer drug development in the future.
Journal ArticleDOI
Polymer‐ and Dendrimer‐Bound Ti‐TADDOLates in Catalytic (and Stoichiometric) Enantioselective Reactions: Are pentacoordinate cationic Ti complexes the catalytically active species?
TL;DR: In this paper, the TADDOL moieties were copolymerized with styrene and divinylbenzene in a suspension, yielding polymers as beads with a rather uniform particle-size distribution (150-45 μm).