Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Journal ArticleDOI
Titanocene-Catalyzed Pinacol Couplings: Reagent-ControlledTransition-Metal-Catalyzed Radical Reactions
TL;DR: In this paper, the titanocene-catalyzed pinacol coupling of aromatic aldehydes is described, with good yields and high diastereoselectivity under reagent control.
Journal ArticleDOI
Biological activities and cytotoxicity of diterpenes from Copaifera spp. Oleoresins.
Fabiano de S. Vargas,Patrícia Danielle Oliveira de Almeida,Elenn Suzany Pereira Aranha,Ana Paula de Araújo Boleti,Peter Newton,Peter Newton,Marne Carvalho de Vasconcellos,Valdir Florêncio da Veiga Junior,Emerson Silva Lima +8 more
TL;DR: This study studied the cytotoxicity and in vitro anti-inflammatory effects of six diterpene acids isolated from the oleoresins of Copaifera spp.
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The Use of Lewis Acids in Radical Chemistry. Chelation-Controlled Radical Reductions of Substituted α-Bromo-β-alkoxy Esters and Chelation-Controlled Radical Addition Reactions
Yvan Guindon,Jean Rancourt +1 more
TL;DR: The radical reduction of a series of α-bromo-β-alkoxy esters under chelation-controlled conditions is reported, suggesting that the monodentate pathway is kinetically favored over the bidentate one.
Journal ArticleDOI
A facile and regiospecific tritiation of sphingosine: Synthesis of (2S,3R,4E)‐2‐amino‐4‐octadecene‐1,3‐diol‐1‐3H
TL;DR: An easy technique for introduction of tritium into the 1-position of sphingosine was developed, employing regiospecific oxidation of the primary hydroxy group followed by reduction with NaB3H4.
Journal ArticleDOI
Environmental and economic analysis for selection and engineering sustainable API degenotoxification processes
TL;DR: In this article, a comparative study concerning performance efficiency and sustainable impact of three purification processes for degenotoxification of active pharmaceutical ingredients (APIs) post reaction streams: recrystallization, flash chromatography and organic solvent nanofiltration (OSN).