Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.
David Lee Musso,Felicia R. Cochran,James L. Kelley,Ed W. McLean,Jeffrey L. Selph,Greg C. Rigdon,G Faye Orr,Ronda Davis,Barrett R. Cooper,Virgil L. Styles,James B. Thompson,William R. Hall +11 more
TL;DR: The synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues are described.
Journal ArticleDOI
Chirale Synthesebausteine durch Kolbe‐Elektrolyse enantiomerenreiner β‐Hydroxy‐carbonsäurederivate. (R)‐ und (S)‐Methyl‐sowie (R)‐Trifluormethyl‐γ‐butyrolactone und ‐δ‐valerolactone
Dieter Seebach,Philippe Renaud +1 more
TL;DR: Chiral Building Blocks for Syntheses by Kolbe Electrolysis of Enantiomerically Pure β-Hydroxybutyric-Acid Derivatives as mentioned in this paper are used to prepare compounds with a 1.4 and 1.5-distance of the functional groups.
Journal ArticleDOI
Synthesis of potential inhibitors of hemagglutination by influenza virus: chemoenzymic preparation of N-5 analogs of N-acetylneuraminic acid.
Michelle A. Sparks,Kevin W. Williams,Christine Lukacs,Andreas Schrell,Gregory P. Priebe,Andreas Spaltenstein,George M. Whitesides +6 more
TL;DR: N-Acylation of 2 produced several new N-acyl neuraminic acid analogs; these have been evaluated as inhibitors of adhesion of influenza virus to chicken erythrocytes in a hemagglutination inhibition assay (HAI).
Journal ArticleDOI
Antifungal phenanthrenes in yam tubers
TL;DR: An extract from the peel of yams showed anti-fungal activity towards both Cladosporium cladoporioides and a variety of ya.
Journal ArticleDOI
The synthesis of 7α-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents
TL;DR: In nearly every case, the 7 alpha-methyl substituent increases ER binding affinity and decreases binding to high affinity serum steroid binding proteins, alphafetoprotein, and sex steroid binding protein, but increases the lipophilicity and the predicted non-specific binding.