Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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[ω‐(Phosphanyl)alkyl]cyclopentadienyl Complexes
TL;DR: In this article, the synthesis and characterisation of the [ω-(phosphanyl)alkyl]cyclopentadienyl anions 2, 3, 6-8, 10, and 11 are described.
Journal ArticleDOI
Asymmetrische Michael‐Additionen. Stereoselektive Alkylierungen des (R)‐ und (S)‐Enamins aus Cyclohexanon und 2‐(Methoxymethyl)pyrrolidin durch α‐(Methoxycarbonyl)zimtsäure‐methylester
Stefan J. Blarer,Dieter Seebach +1 more
TL;DR: In this paper, an asymmetric Michael addition of enamines from cyclohexanone and enamine from 2-(methoxymethylpyrrolidine) was proposed.
Journal ArticleDOI
Palladium-catalysed coupling of vinyl triflates with enynes and its application to the synthesis of 1α,25-dihydroxyvitamin D3☆
TL;DR: In this paper, a general approach based on the palladium-catalysed coupling of enynes with vinyl triflates was described for the construction of dienynes related to vitamin D metabolites and analogues.
Journal ArticleDOI
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.
C. Todd Eary,Zachary Jones,Robert D. Groneberg,Laurence E. Burgess,David A. Mareska,Mark D. Drew,James F. Blake,Ellen R. Laird,Devan Balachari,Michael O'sullivan,Andrew Allen,Vivienne Marsh +11 more
TL;DR: This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early mu lead to advanced enantiomerically pure analogs.
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p-maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling
TL;DR: PMPI is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling and activation of vitamin B12, digoxigenin, digitoxigen in, estradiol, progesterone, and some serine-containing peptides.