Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
TL;DR: The first general method has been developed for the expedient solid-phase synthesis of ketone-based cysteine protease inhibitors using readily available precursors and racemization of the α-stereocenter does not occur during loading onto support, nucleophilic displacement, or cleavage from support.
Journal ArticleDOI
Photochromism of a Furylfulgide, 2-[1-(2,5-Dimethyl-3-furyl)ethylidene]-3-isopropylidenesuccinic Anhydride in Solvents and Polymer Films
TL;DR: In this paper, the quantum yields of photochromic reaction between (E)- and (Z)-2-[1-(2,5-dimethyl-3-furyl)ethylidene]-3-isopropylidenesuccinic anhydride and the cyclized valence isomer were determined in various solvents and polymers.
Journal ArticleDOI
A modular and enantioselective synthesis of the pleuromutilin antibiotics
TL;DR: A synthetic route to pleuromutilin that allows the configurations in that segment of the molecule to be varied, offering a distinct path for structural optimization and facilitating targeted stereochemical variation for optimization of antibiotic properties is presented.
Journal ArticleDOI
Chirale Lactole, II. Racematspaltung und enantioselektive Acetalisierung mit der 2,3,3a,4,5,6,7,7a‐Octahydro‐7,8,8‐trimethyl‐4,7‐methanobenzofuran‐2‐yl‐Schutzgruppe
TL;DR: In this article, a simple method for the resolution of the chiral alcohols, cyanohydrins, thiols and amines by the reaction with a chiral protective group was described.
Journal ArticleDOI
Asymmetrische Michael‐Additionen. Regio‐, diastereo‐ und enantioselektive Alkylierungen der Enamine aus β‐Tetralonen und (S)‐2‐(Methoxymethyl)pyrrolidin („Prolinolmethylether”︁) durch ω‐Nitrostyrole
Stefan J. Blarer,Dieter Seebach +1 more
TL;DR: In this article, β-Tetralone with various substitutents (CH3, NO2, OCH3 and OCH2O, Cl) in 1-, 5-, 6-, 7- and 8-Stellung were added to ω-nitrostyrenes through enamines derived from (S)-2-(methoxymethyl)pyrrolidine.