Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Prokaryotic triterpenoids. 2. 2 beta-Methylhopanoids from Methylobacterium organophilum and Nostoc muscorum, a new series of prokaryotic triterpenoids.
TL;DR: 2 beta-Methylhopanoids, a new series of triterpenoids was identified from two prokaryotes, and the structures of these compounds was deduced by direct comparison with 2 beta-methyldiplopterol synthesized from 22-hydroxyhopan-3-one.
Journal ArticleDOI
Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
Noel D'angelo,Tae-Seong Kim,Kristin L. Andrews,Shon Booker,Sean Caenepeel,Kui Chen,Derin C. D'amico,Daniel J. Freeman,Jian Jiang,Longbin Liu,John D. McCarter,Tisha San Miguel,Erin L. Mullady,Michael Schrag,Raju Subramanian,Jin Tang,Robert C. Wahl,Ling Wang,Douglas A. Whittington,Tian Wu,Ning Xi,Yang Xu,Peter Yakowec,Kevin Yang,Leeanne Zalameda,Nancy Zhang,Paul E. Hughes,Mark H. Norman +27 more
TL;DR: This work reports the discovery of compound 82 as a potent dual inhibitor of PI3K and mTOR, which exhibited potent enzyme and cell activity, low clearance, and high oral bioavailability and demonstrated tumor growth inhibition in U-87 MG, A549, and HCT116 tumor xenograft models.
Journal ArticleDOI
Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.
TL;DR: In this paper, comparative molecular field analysis (CoMFA) was used to predict the A2A selectivity and predictability for rat brain receptors with differences in their structural and electrostatic properties.
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Studies on the Synthesis of Nargenicin A1: Highly Stereoselective Synthesis of the Complete Carbon Framework via the Transannular Diels−Alder Reaction of an 18-Membered Macrolide
TL;DR: In this article, the complete carbon skeleton of the nargenicins, represented by tricyclic lactone 45, is described, and the key step of the synthesis of 45 is the Yamaguchi macrolactonization of hydroxy acid 44 which is followed by the facile transannular Diels−Alder reaction of the 18-membered macrolide 22.
Journal ArticleDOI
Acylnitrene Route to Vicinal Amino Alcohols. Application to the Synthesis of (-)-Bestatin and Analogues.
TL;DR: This synthesis utilizes an intramolecular acylnitrene-mediated aziridination to generate a key bicyclic aziridine in excellent yield and stereoselectivity and has demonstrated that oxazolidinones can be selectively hydrolyzed in the presence of peptide bonds.