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Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Catalytic oxidation of reduced nicotinamide adenine dinucleotide by graphite electrodes modified with adsorbed aromatics containing catechol functionalities
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Direct β-Alkylation of Aldehydes via Photoredox Organocatalysis
TL;DR: Mechanistic studies by various spectroscopic methods suggest that a reductive quenching pathway is operable and this redox-neutral, atom-economical C–H functionalization protocol can be achieved both inter- and intramolecularly.
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Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.
Lawrence G. Hamann,Robert I. Higuchi,Lin Zhi,James P. Edwards,Xiao-Ning Wang,Keith B. Marschke,James W. Kong,Luc J. Farmer,Todd K. Jones +8 more
TL;DR: Investigations of structure-activity relationships surrounding this pharmacophore resulted in molecules with complete specificity for AR, antagonist activity on an AR mutant commonly observed in prostate cancer patients, and improved in vivo efficacy.
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Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum).
Lyle Ralston,Soon Tae Kwon,Mark A. Schoenbeck,Jennifer Ralston,David J. Schenk,Robert M. Coates,Joseph Chappell +6 more
TL;DR: An in vivo assay for 5-epi-aristolochene hydroxylase activity was developed and used to demonstrate a dose-dependent inhibition of activity by ancymidol and ketoconazole, two well characterized inhibitors of cytochrome P450 enzymes.
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