Journal ArticleDOI
Rapid chromatographic technique for preparative separations with moderate resolution
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Abstract:
(11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).read more
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Suicide inhibitors of cytochrome P450 1A1 and P450 2B1.
TL;DR: Because a precise orientation of the terminal acetylene is required to produce suicide inhibition without heme destruction, acetylenic suicide inhibitors can potentially be used to differentiate between P450 isozymes and to establish some distinguishing geometric features of the active site of these isoz enzymes.
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Direct epoxidation of D-glucal and D-galactal derivatives with in situ generated DMDO.
TL;DR: A multi-gram epoxidation of 3,4,6-tri-O-benzyl-D-glucal and D-galactal with dimethyldioxirane with DMDO generated in situ from Oxone/acetone in a biphasic system resulted in the formation of the corresponding 1,2-anhydrosugars in a 99% yield and 100% selectivity.
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Deconvoluting the Memory Effect in Pd‐Catalyzed Allylic Alkylation: Effect of Leaving Group and Added Chloride
TL;DR: An analysis of product distributions in the Tsuji-Trost reaction indicates that several instances of reported "memory effects" can be attributed to slow interconversion of the initially formed syn- and anti-[Pd(eta3-allyl)] complexes.
Journal ArticleDOI
Terpene biosynthesis by nasute termite soldiers (Isoptera: Nasutitermitinae)
TL;DR: Chromatographic isolation of pure mono- and di-terpenoid compounds unambiguously demonstrated incorporation of labelled precursors into the soldier defence secretions in vivo and it is noteworthy that the soldier biosynthetic enzymes operate independent of any metabolic assistance from worker termites.
Journal ArticleDOI
Azole Phenoxy Hydroxyureas as Selective and Orally Active Inhibitors of 5-Lipoxygenase
Michael S. Malamas,R. P. Carlson,D. Grimes,Ralph Howell,Keith B. Glaser,Iwan Gunawan,James Albert Nelson,Mira Ana Kanzelberger,Uresh Shantilal Shah,D. A. Hartman +9 more
TL;DR: Azole phenoxy hydroxyureas are a new class of 5-lipoxygenase (5-LO) inhibitors that have high and selective 5-LO inhibitory activity in the in vitro assays, and Oxazole 59 was the most active inhibitor in the human monocyte assay with an IC50 value of 7 nM.