The Human Connectome: A Structural Description of the Human Brain
Reads0
Chats0
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
More filters
Journal ArticleDOI
Synchronizing Hindmarsh-Rose neurons over Newman-Watts networks.
TL;DR: The synchronization behavior of the Hindmarsh-Rose neuron model over Newman-Watts networks is investigated and it is found that the synchronizing coupling strength is influenced mainly by the probability of intercluster connections with a power-law relation.
Journal ArticleDOI
The neuroaesthetics of prose fiction: pitfalls, parameters and prospects.
TL;DR: The aim of this article is to stimulate, excite and energize thinking in the discipline as to how prose fiction might be fully integrated in the canon of neuroaesthetics and to point to opportunities where neuroimaging studies on literary discourse processing might be conducted in collaborative work bringing humanists and scientists together.
Posted ContentDOI
Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics
Ane López-González,Rajanikant Panda,Adrián Ponce-Alvarez,Gorka Zamora-López,Anira Escrichs,Charlotte Martial,Aurore Thibaut,Olivia Gosseries,Morten L. Kringelbach,Morten L. Kringelbach,Morten L. Kringelbach,Jitka Annen,Steven Laureys,Gustavo Deco +13 more
TL;DR: It is shown that pathological and pharmacological low-level states of consciousness displayed less recurrent, less diverse, less connected, and more segregated synchronization patterns than conscious states, and altered dynamics arise from a global reduction of network interactions, together with more homogeneous and more structurally constrained local dynamics.
Journal ArticleDOI
Probabilistic Clustering of the Human Connectome Identifies Communities and Hubs
TL;DR: A probabilistic model for connectivity-based parcellation of the human brain is introduced that allows quantification of the uncertainty in cluster assignments and shows that, while most clusters are clearly delineated, some regions are more difficult to assign.
Journal ArticleDOI
Big data, small kids: Medico-scientific, familial and advocacy visions of human brains
TL;DR: This article traces the recent move from studies of individual diagnostic pathologies like ADHD, Tourette or autism spectrum disorder to the rapid creation of innovative interdisciplinary research coalitions and collaborations that both produce and utilize big data techniques in order to map the human connectome.
References
More filters
Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
Related Papers (5)
Complex brain networks: graph theoretical analysis of structural and functional systems
Edward T. Bullmore,Olaf Sporns +1 more
Complex network measures of brain connectivity: uses and interpretations.
Mikail Rubinov,Olaf Sporns +1 more