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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Revealing physical interaction networks from statistics of collective dynamics.

TL;DR: This work exploits changes in invariant measures, in particular distributions of sampled states of the system in response to driving signals, and uses compressed sensing to reveal physical interaction networks in complex synthetic and natural systems.
Posted Content

Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints

TL;DR: In this paper, the authors studied the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography, and proposed a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC.
Journal ArticleDOI

Neuroscience: Towards functional connectomics

TL;DR: Using a combination of functional imaging and three-dimensional serial electron-microscopic reconstruction at an unprecedented scale, two groups present detailed representations of the connectivity of single cells in the mouse visual system.
Journal ArticleDOI

Communication and wiring in the cortical connectome.

TL;DR: The hypothesized trade-off between spatial and temporal costs may potentially offer a powerful explanation for cortical wiring patterns.
Journal ArticleDOI

Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery

TL;DR: The authors describe the ideas and concepts behind the connectome and its analysis with graph theory and highlight selected insights into healthy brain function that have been derived from connectome analysis and illustrate how studies into normal development, cognitive function, and the effects of synthetic lesioning can be relevant to neurosurgery.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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