The Human Connectome: A Structural Description of the Human Brain
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Journal ArticleDOI
Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey
Chad J. Donahue,Stamatios N. Sotiropoulos,Saad Jbabdi,Moises Hernandez-Fernandez,Timothy E.J. Behrens,Tim B. Dyrby,Timothy S. Coalson,Henry Kennedy,Kenneth Knoblauch,David C. Van Essen,Matthew F. Glasser +10 more
TL;DR: Evaluated tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex is evaluated by comparing its results with published data from retrograde tracer injections, and a novel method for calculating interareal cortical distances is used.
Journal ArticleDOI
The Neonatal Connectome During Preterm Brain Development
Martijn P. van den Heuvel,Karina J. Kersbergen,Marcel A. de Reus,Kristin Keunen,René S. Kahn,Floris Groenendaal,Linda S. de Vries,Manon J.N.L. Benders +7 more
TL;DR: It is concluded that hallmark organizational structures of the human connectome are present before term birth and subject to early development.
Journal ArticleDOI
Exploring the network dynamics underlying brain activity during rest.
TL;DR: An overview of the key findings of resting-state activity covering a range of neuroimaging modalities is provided and how to best define and analyze anatomical and functional brain networks is described and how unbalancing these networks may lead to problems with mental health is described.
Journal ArticleDOI
Graph theory methods: applications in brain networks.
TL;DR: A brief review surveys some of the most commonly used and neurobiologically insightful graph measures and techniques, including the detection of network communities or modules, and the identification of central network elements that facilitate communication and signal transfer.
Journal ArticleDOI
Rich Club Organization of Macaque Cerebral Cortex and Its Role in Network Communication
TL;DR: Evidence is presented for the existence of rich club organization in the cerebral cortex of a non-human primate, the macaque monkey, based on a connectivity data set representing a collation of numerous tract tracing studies that supports the hypothesis that rich club regions and connections have a central role in global brain communication.
References
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Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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