The Human Connectome: A Structural Description of the Human Brain
Reads0
Chats0
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
More filters
Journal ArticleDOI
Clinical correlates of graph theory findings in temporal lobe epilepsy
TL;DR: Graph theory allows for a network-based representation of TLE brain networks using several neuroimaging and electrophysiologic modalities, and has potential to provide clinicians with clinically useful biomarkers for diagnostic and prognostic purposes.
Proceedings ArticleDOI
Multi-stage Multi-recursive-input Fully Convolutional Networks for Neuronal Boundary Detection
TL;DR: In this paper, a multi-stage multi-recursive input fully convolutional networks (MRCNN) was proposed to segment the EM images and achieve promising results on two public available EM segmentation datasets, the mouse piriform cortex dataset and the ISBI 2012 EM dataset.
Journal ArticleDOI
Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.
Jonathan Wirsich,Alistair Perry,Ben Ridley,Timothée Proix,Mathieu Golos,Christian Bénar,Jean-Philippe Ranjeva,Fabrice Bartolomei,Michael Breakspear,Michael Breakspear,Viktor K. Jirsa,Maxime Guye +11 more
TL;DR: Global augmentation of structure-function correlation might be linked to a smaller functional repertoire in rTLE patients, while sparing the central core of the brain which may represent a pathway that facilitates the spread of seizures.
Journal ArticleDOI
Constraints and spandrels of interareal connectomes
TL;DR: It is shown that empirical wiring-cost constraints inadequately explain connectome module organization, and that simultaneous module and hub constraints induce the structural byproducts of hierarchies and rich clubs.
Journal ArticleDOI
Test-retest reproducibility of white matter parcellation using diffusion MRI tractography fiber clustering.
TL;DR: The experimental results in general indicate that the fiber clustering method produced more reproducible white matter parcellations than the cortical‐parcellation‐based method.
References
More filters
Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
Related Papers (5)
Complex brain networks: graph theoretical analysis of structural and functional systems
Edward T. Bullmore,Olaf Sporns +1 more
Complex network measures of brain connectivity: uses and interpretations.
Mikail Rubinov,Olaf Sporns +1 more