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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Tracking Dynamic Interactions Between Structural and Functional Connectivity: A TMS/EEG-dMRI Study

TL;DR: This study points out the importance of taking into account the major role played by different cortical oscillations when investigating the mechanisms for integration and segregation of information in the human brain.
Book ChapterDOI

Critical Brain Dynamics at Large Scale

TL;DR: The idea put forward two decades ago by Per Bak that the working brain stays at an intermediate regime characterized by power-law correlations is supported by a wide body of empirical evidence at different scales demonstrating that the spatiotemporal brain dynamics exhibit key signatures of critical dynamics.
Journal ArticleDOI

Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study

TL;DR: Findings in GM volume (GMV) changes in a relatively large sample of treatment-naive first-episode schizophrenia patients using optimized voxel-based morphometry (VBM) and covariation analysis cannot be attributable to the effects of chronic illness progression or medication.
Journal ArticleDOI

Tune the topology to create or destroy patterns

TL;DR: In this article, the authors consider the dynamics of a reaction-diffusion system on a multigraph, where the species share the same set of nodes but can access different links to explore the embedding spatial support.
Journal ArticleDOI

Structural Pathways Supporting Swift Acquisition of New Visuomotor Skills.

TL;DR: For example, this paper found that increased white matter connectivity linking early visual regions was associated with a faster learning rate, and the strength of multiedge paths between motor and visual modules was also correlated with learning rate.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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