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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Denoise magnitude diffusion magnetic resonance images via variance-stabilizing transformation and optimal singular-value manipulation

TL;DR: The results show that the proposed denoising framework can significantly improve SNR across the entire brain, leading to substantially enhanced performances for estimating diffusion tensor related indices and for resolving crossing fibers when compared to another competing method.
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Individuality manifests in the dynamic reconfiguration of large-scale brain networks during movie viewing

TL;DR: Arousal level significantly modulates inter-subject variability in functional connectivity, edge patterns, and modularity, and particularly enhances the synchrony of rich-club edges, implying that individuality resides in the dynamic reconfiguration of large-scale brain networks in response to a stream of cognitive demands.
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Graph Theoretic and Motif Analyses of the Hippocampal Neuron Type Potential Connectome.

TL;DR: The potential connectivity map of all known neuron types in the rodent hippocampal formation is computed by supplementing scantly available synaptic data with spatial distributions of axons and dendrites from the open-access knowledge base Hippocampome.org, yielding novel insights on its functional operations at the computationally crucial level of neuron types.
Journal ArticleDOI

Graph representation learning in bioinformatics: trends, methods and applications.

TL;DR: Graph representation learning aims to embed graph into a low-dimensional space while preserving graph topology and node properties as mentioned in this paper, which has recently raised widespread interest in both machine learning and bioinformatics communities.
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Is brain connectome research the future frontier for subjective cognitive decline? A systematic review

TL;DR: A systematic literature review on Subjective Cognitive Decline examined whether the resemblance of brain connectome and functional connectivity alterations in SCD with respect to MCI, AD and HC can help to draw conclusions on the progression of SCD to more advanced stages of dementia.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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