The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Brain Morphological Dynamics of Procrastination: The Crucial Role of the Self-Control, Emotional, and Episodic Prospection Network
TL;DR: The brain morphological dynamics involving in self-control, emotion, and episodic prospection brain network for procrastination was ascertained, which advanced promising aspects of the biomarkers for it.
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The intrinsic geometry of the human brain connectome.
Allen Q. Ye,Olusola Ajilore,Giorgio Conte,Johnson GadElkarim,Galen Thomas-Ramos,Liang Zhan,Shaolin Yang,Anand Kumar,Richard L. Magin,Angus G. Forbes,Alex D. Leow +10 more
TL;DR: Novel methods for constructing the intrinsic geometry of the human brain connectome using dimensionality-reduction techniques are described, showing that the high-dimensional, complex geometry that represents this intrinsic topology can be mathematically embedded into lower dimensions using coupling patterns encoded in the corresponding brain connectivity graphs.
Journal ArticleDOI
Toward Whole-Body Connectomics.
Chung-Chuan Lo,Ann-Shyn Chiang +1 more
TL;DR: The current state of connectomics study is discussed, focusing on novel optical approaches and related imaging technologies, and the challenges encountered by scientists who endeavor to map these whole-body connectomes in large animals.
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Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function
Júlia Ballester-Plané,Ruben Schmidt,Olga Laporta-Hoyos,Carme Junqué,Elida Vazquez,Ignacio Delgado,Leire Zubiaurre-Elorza,Alfons Macaya,P Póo,Esther Toro,Marcel A. de Reus,Martijn P. van den Heuvel,Roser Pueyo +12 more
TL;DR: A disruption in structural brain connectivity in dyskinetic CP is demonstrated, revealing general involvement of posterior brain regions with relative preservation of prefrontal areas and pathways in which WM integrity is related to clinical features, including but not limited to the sensorimotor system.
Journal ArticleDOI
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury
Andrew D. Sauerbeck,Mihika Gangolli,Sydney J. Reitz,Maverick H. Salyards,Samuel H. Kim,Christopher Hemingway,Maud Gratuze,Tejaswi Makkapati,Martin Kerschensteiner,David M. Holtzman,David L. Brody,Terrance T. Kummer +11 more
TL;DR: A rapid, accessible super-resolution imaging and analysis workflow-SEQUIN-that quantifies central synapses in human tissue and animal models, characterizes their nanostructural and molecular features, and enables volumetric imaging of mesoscale synaptic networks without the production of large histological arrays is described.
References
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