The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Effects of amyloid and small vessel disease on white matter network disruption.
Hee Jin Kim,Kiho Im,Hunki Kwon,Jongmin Lee,Byoung Seok Ye,Yeo Jin Kim,Hanna Cho,Yearn Seong Choe,Kyung-Han Lee,Sung Tae Kim,Jae Seung Kim,Jae-Hong Lee,Duk L. Na,Sang Won Seo +13 more
TL;DR: It is suggested that SVD alters white matter network integration and segregation, which further predicts cognitive dysfunction, and the whole-brain network was assessed.
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White matter alterations in the internal capsule and psychomotor impairment in melancholic depression
Matthew P. Hyett,Matthew P. Hyett,Alistair Perry,Alistair Perry,Michael Breakspear,Michael Breakspear,Michael Breakspear,Wei Wen,Gordon Parker,Gordon Parker +9 more
TL;DR: This study clarifies the contribution of structural brain integrity to the phenomenology of melancholia, and may assist future efforts seeking to integrate neurobiological markers into depression subtyping.
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Mapping the human middle longitudinal fasciculus through a focused anatomo-imaging study: shifting the paradigm of its segmentation and connectivity pattern
Aristotelis V. Kalyvas,Christos Koutsarnakis,Spyridon Komaitis,Efstratios Karavasilis,Foteini Christidi,Georgios P. Skandalakis,Evangelia Liouta,Olympia Papakonstantinou,Nikolaos Kelekis,Hugues Duffau,George Stranjalis +10 more
TL;DR: Investigation of the ambiguous structural architecture of the middle longitudinal fasciculus through focused cadaveric dissections augmented by a tailored DTI protocol in healthy participants from the Human Connectome dataset found three segments that could underpin the perception of auditory representations and could potentially subserve the integration of auditory and visual information.
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Data-driven approaches for identifying links between brain structure and function in health and disease.
TL;DR: Data-driven approaches, which leverage higher order statistics to link together macroscopic structural and functional MRI data, are reviewed, including several showing the potential of such approaches to inform us about mental illness, particularly about schizophrenia.
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The brain near the edge
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