The Human Connectome: A Structural Description of the Human Brain
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Understanding complexity in the human brain
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Hierarchical organization of cortical and thalamic connectivity
Julie A. Harris,Stefan Mihalas,Karla E. Hirokawa,Jennifer D. Whitesell,Hannah Choi,Hannah Choi,Amy Bernard,Phillip Bohn,Shiella Caldejon,Linzy Casal,Andrew Cho,Aaron Feiner,David Feng,Nathalie Gaudreault,Charles R. Gerfen,Nile Graddis,Peter A. Groblewski,Alex M. Henry,Anh Ho,Robert Howard,Joseph E. Knox,Leonard Kuan,Xiuli Kuang,Jérôme Lecoq,Phil Lesnar,Yaoyao Li,Jennifer Luviano,Stephen McConoughey,Marty Mortrud,Maitham Naeemi,Lydia Ng,Seung Wook Oh,Benjamin Ouellette,Elise Shen,Staci A. Sorensen,Wayne Wakeman,Quanxin Wang,Yun Wang,Ali Williford,John W. Phillips,Allan R. Jones,Christof Koch,Hongkui Zeng +42 more
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The Cell-Type Specific Cortical Microcircuit: Relating Structure and Activity in a Full-Scale Spiking Network Model
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References
More filters
Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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