The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Evidence from Blindness for a Cognitively Pluripotent Cortex.
TL;DR: It is proposed that human cortices are cognitively pluripotent, that is, capable of assuming a wide range of cognitive functions, and driven by input during development, which is itself constrained by connectivity and experience.
Journal ArticleDOI
Modeling and interpreting mesoscale network dynamics.
TL;DR: Recent advances in a range of modeling approaches that embrace the temporally-evolving interconnected structure of the brain and summarize that structure in a dynamic graph are reviewed.
Journal ArticleDOI
Disrupted structural and functional brain networks in Alzheimer's disease.
Zhengjia Dai,Zhengjia Dai,Qixiang Lin,Qixiang Lin,Tao Li,Xiao Wang,Huishu Yuan,Xin Yu,Yong He,Yong He,Huali Wang +10 more
TL;DR: Overlap and distinct network disruptions in the FCN and SCN and a strengthened correlation between FCNs and SCNs in AD are demonstrated, which provides a novel perspective for understanding the pathophysiological mechanisms underlying AD.
Journal ArticleDOI
Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints.
Fang-Cheng Yeh,Jean M. Vettel,Aarti Singh,Barnabás Póczos,Scott T. Grafton,Kirk I. Erickson,Wen-Yih Isaac Tseng,Timothy Verstynen +7 more
TL;DR: This novel approach that uses diffusion MRI to characterize whole-brain white matter architecture as a single local connectome fingerprint that allows for a direct comparison between structural connectomes opens a new door for probing the influence of pathological, genetic, social, or environmental factors on the unique configuration of the human connectome.
Journal ArticleDOI
Topological graph kernel on multiple thresholded functional connectivity networks for mild cognitive impairment classification
TL;DR: Connectivity analysis indicates that the connectivity of the selected brain regions is different between MCI patients and NC, that is,MCI patients show reduced functional connectivity compared with NC, in line with the findings reported in the existing studies.
References
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