The Human Connectome: A Structural Description of the Human Brain
Reads0
Chats0
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
More filters
Journal Article
Altered topological organisation of white matter structural networks in patients with neuromyelitis optica
Yaou Liu,Yunyun Duan,Yong He,Jun Wang,Mingrui Xia,Chunshui Yu,Huiqing Dong,Jing Ye,Helmut Butzkueven,Kuncheng Li,Ni Shu +10 more
Journal ArticleDOI
Validation of structural brain connectivity networks: The impact of scanning parameters
Karen Sando Ambrosen,Simon Fristed Eskildsen,Max Hinne,Kristine Krug,Henrik Lundell,Mikkel N. Schmidt,Marcel A. J. van Gerven,Morten Mørup,Tim B. Dyrby +8 more
TL;DR: It is found that high angular resolution and high signal-to-noise ratio are important to estimate SC, and that SC derived from low image resolution are in better agreement with the tracer network, than those derived from high image resolution or at an even lower image resolution.
Journal ArticleDOI
Markov models for fMRI correlation structure: Is brain functional connectivity small world, or decomposable into networks?
TL;DR: It is found that summarizing the structure as strongly-connected networks can give a good description only for very large and overlapping networks, highlighting that Markov models are good tools to identify the structure of brain connectivity from fMRI signals, but for this purpose they must reflect the small-world properties of the underlying neural systems.
Journal ArticleDOI
Cultural Exaptation and Cultural Neural Reuse: A Mechanism for the Emergence of Modern Culture and Behavior
TL;DR: This paper proposed a plausible biocultural mechanism at the basis of cultural evolution, which relies on the notions of cultural exaptation and cultural neural reuse, may account for the asynchronous, discontinuous, and patchy emergence of innovations around the globe.
Journal ArticleDOI
The semantic anatomical network: Evidence from healthy and brain-damaged patient populations.
Yuxing Fang,Zaizhu Han,Suyu Zhong,Gaolang Gong,Luping Song,Fangsong Liu,Ruiwang Huang,Xiaoxia Du,Rong Sun,Qiang Wang,Yong He,Yanchao Bi +11 more
TL;DR: The semantic anatomical network (connectome) is mapped by conducting diffusion imaging tractography in 48 healthy participants across 90 GM “nodes,” and correlating the integrity of each obtained WM edge and semantic performance across 80 brain‐damaged patients.
References
More filters
Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
Related Papers (5)
Complex brain networks: graph theoretical analysis of structural and functional systems
Edward T. Bullmore,Olaf Sporns +1 more
Complex network measures of brain connectivity: uses and interpretations.
Mikail Rubinov,Olaf Sporns +1 more