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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Enriched white matter connectivity networks for accurate identification of MCI patients.

TL;DR: This work proposes an effective network-based multivariate classification algorithm, using a collection of measures derived from white matter (WM) connectivity networks, to accurately identify MCI patients from normal controls and found that portions of the prefrontal cortex, orbitofrontal cortex, parietal lobe and insula regions provided the most discriminant features for classification, in line with results reported in previous studies.
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Neuromorphic silicon neurons and large-scale neural networks: challenges and opportunities.

TL;DR: In the inaugural issue of this Journal, Indiveri et al. (2011) review the current state of the art in CMOS-based neuromorphic neuron circuit designs that have evolved over the past two decades and delineates and compares the latest SiN design techniques as applied to varying types of spiking neuron models ranging from realistic conductancebased Hodgkin–Huxley models to simple yet versatile integrate-and-fire models.
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Discrete Neuroanatomical Networks Are Associated with Specific Cognitive Abilities in Old Age

TL;DR: Greater processing speed was significantly correlated with better connectivity of nearly all the cortical regions, and regional anatomical connectivity maps related to processing speed and visuospatial and executive functions in the elderly are identified.
Journal ArticleDOI

Small-world connectivity, motif composition, and complexity of fractal neuronal connections.

TL;DR: A simple procedure to generate fractal connection patterns that aim at capturing the potential self-similarity and hierarchical ordering of neuronal connections, and measures obtained from some modeled fractal patterns closely resemble those of real neuroanatomical data sets, supporting the original hypothesis.
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Network dysfunction in Alzheimer's disease and frontotemporal dementia: implications for psychiatry.

TL;DR: Emerging evidence of large-scale network dysfunction in Alzheimer's disease and behavioral variant frontotemporal dementia is summarized, focusing on the divergent impact these disorders have on the default mode network and the salience network.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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