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The Human Connectome: A Structural Description of the Human Brain

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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

A novel brain partition highlights the modular skeleton shared by structure and function

TL;DR: This work adopts a systems approach, relying on modular hierarchical clustering, to study together SC and rsFC datasets gathered independently from healthy human subjects, and describes the emerging common structure-function modules (SFMs) in detail and compares them with commonly employed anatomical or functional parcellations.
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Can the macro beat the micro? Integrated information across spatiotemporal scales.

TL;DR: The results show that for systems characterized by indeterminism and/or degeneracy, Φ can indeed peak at a macro level, and the notions of macro causal emergence and micro causal exclusion hold when causal power is assessed in full and from the intrinsic perspective of a system.
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Motor cognition–motor semantics: Action perception theory of cognition and communication

TL;DR: Mechanisms relevant to mechanistic action perception theory are explained, concrete neuronal circuits in brains along with artificial neuronal network simulations are pointed to, and recent brain imaging and other experimental data documenting the role of action perception circuits in cognition, language and communication are summarized.
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Cartography and Connectomes

TL;DR: In humans, advances in analyzing "structural" and "functional" connectivity using powerful but indirect noninvasive neuroimaging methods are yielding intriguing insights about brain circuits, their variability across individuals, and their relationship to behavior.
Journal ArticleDOI

Anatomical dysconnectivity in bipolar disorder compared with schizophrenia: A selective review of structural network analyses using diffusion MRI

TL;DR: Converging evidence indicates that frontal connectivity alterations are common to both disorders, with prominent fronto-temporal deficits identified in schizophrenia and inter-hemispheric and limbic alterations reported in bipolar disorder.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
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Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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