The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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PANDA: a pipeline toolbox for analyzing brain diffusion images
TL;DR: A MATLAB toolbox named “Pipeline for Analyzing braiN Diffusion imAges” (PANDA) is developed, expected to substantially simplify the image processing of dMRI datasets and facilitate human structural connectome studies.
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Structural foundations of resting-state and task-based functional connectivity in the human brain
Ann M Hermundstad,Danielle S. Bassett,Kevin S. Brown,Kevin S. Brown,Elissa Aminoff,David Clewett,Scott Freeman,Amy Frithsen,Arianne Johnson,Christine M. Tipper,Michael B. Miller,Scott T. Grafton,Jean M. Carlson +12 more
TL;DR: It is shown that structural properties, including the length, number, and spatial location of white matter streamlines, are indicative of and can be inferred from the strength of resting-state and task-based functional correlations between brain regions.
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Can structure predict function in the human brain
TL;DR: Although future models will need to be tested more quantitatively and against a wider range of empirical neurodynamic features, the present large-scale models can already predict the macroscopic pattern of dynamic correlation across the brain.
Journal ArticleDOI
Small-World Brain Networks Revisited.
TL;DR: It is highlighted by highlighting some possible future trends in the further development of weighted small-worldness as part of a deeper and broader understanding of the topology and the functional value of the strong and weak links between areas of mammalian cortex.
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Modeling the impact of lesions in the human brain.
Jeff Alstott,Michael Breakspear,Patric Hagmann,Patric Hagmann,Leila Cammoun,Leila Cammoun,Olaf Sporns +6 more
TL;DR: The model suggests that dynamic lesion effects can be predicted on the basis of specific network measures of structural brain networks and that these effects may be related to known behavioral and cognitive consequences of brain lesions.
References
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