scispace - formally typeset
Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

Reads0
Chats0
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Long-term reorganization of structural brain networks in a rabbit model of intrauterine growth restriction.

TL;DR: Interestingly, when assessing the brain network organization independently of network infrastructure by means of normalized networks, IUGR showed increased global and local efficiencies, and it is hypothesized that this effect could reflect a compensatory response to reduced infrastructure in IugR.
Journal ArticleDOI

Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder

TL;DR: The finding provides the first systematic evidence that depression is associated with frequency specific global and local topological disruptions and highlights the importance of frequency information in investigating major depressive disorders.
Book ChapterDOI

Common neural signatures of psychedelics: Frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition

TL;DR: The novel concepts of connectome harmonics and connectome-harmonic decomposition are described, which can be used to characterize the brain activity associated with any mental state and provide new evidence for the remarkable ability of psychedelics to change the spatiotemporal dynamics of the human brain.
Journal ArticleDOI

Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI

TL;DR: Diffusion MRI-based techniques in combination with histology approaches can support the endeavor of creating multimodal atlases that take into account the different spatial scales or levels on which the brain is organized.
Journal ArticleDOI

Insight in schizophrenia: from conceptualization to neuroscience.

TL;DR: The aim of this study was to synthesize findings across the large body of literature dealing with insight, to highlight its multidimensional nature, measurement, neuropsychology and social impact in schizophrenia.
References
More filters
Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
Related Papers (5)