The Human Connectome: A Structural Description of the Human Brain
TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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The structural connectome constrains fast brain dynamics
Pierpaolo Sorrentino,Caio Seguin,Rosaria Rucco,Marianna Liparoti,Emahnuel Troisi Lopez,Simona Bonavita,Mario Quarantelli,Giuseppe Sorrentino,Viktor K. Jirsa,Andrew Zalesky +9 more
TL;DR: In this article, the authors use magnetoencephalography (MEG) to quantify the extent to which fast neural dynamics in the human brain are constrained by structural connections inferred from diffusion MRI tractography.
Journal ArticleDOI
Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics
Ane López-González,Rajanikant Panda,Adrián Ponce-Alvarez,Gorka Zamora-López,Anira Escrichs,Charlotte Martial,Aurore Thibaut,Olivia Gosseries,Morten L. Kringelbach,Morten L. Kringelbach,Morten L. Kringelbach,Jitka Annen,Steven Laureys,Gustavo Deco,Gustavo Deco +14 more
TL;DR: In this article, the structural, dynamical, local and network brain properties interplay in the different levels of consciousness is unknown, and the authors use whole-brain models built upon healthy and injured structural connectivity to interpret these dynamical effects.
Journal ArticleDOI
Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.
Zhuo Wang,Marco A. Ocampo,Raina D. Pang,Mihail Bota,Sylvie Bradesi,Sylvie Bradesi,Emeran A. Mayer,Emeran A. Mayer,Daniel P. Holschneider +8 more
TL;DR: The altered pattern of functional brain activation in stressed rats is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS.
Journal ArticleDOI
Revealing networks from dynamics: an introduction
TL;DR: In this article, the authors review recent progress on how to infer structural connectivity (direct interactions) from accessing the dynamics of the units and briefly mention some standard ways of inferring effective or functional connectivity.
Journal ArticleDOI
The functional brain connectome of the child and autism spectrum disorders
Katell Mevel,Peter Fransson +1 more
TL;DR: The theory behind the brain connectome concept is described and its applicability to studying the development and dynamics of brain networks through graph theoretical metrics is described.
References
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