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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Book

Semigroup Methods for Evolution Equations on Networks

TL;DR: In this article, a crash course in Cortical Modeling is described, with a focus on the evolution of self-adjoint operators in the context of function spaces on networks.
Journal ArticleDOI

The brain as a complex system: using network science as a tool for understanding the brain.

TL;DR: To fully appreciate the utility of network science, a greater understanding of how network models apply to the brain is needed, and an integrated appraisal of multiple network analyses should be performed to better understand network structure.
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The effects of SIFT on the reproducibility and biological accuracy of the structural connectome.

TL;DR: The combination of sources of evidence demonstrates the important role the SIFT methodology has for the robust quantification of structural connectivity of the brain using diffusion MRI.
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Learning and comparing functional connectomes across subjects.

TL;DR: A review of methods of estimating functional connectomes from the imaging signal aims to clarify links across functional-connectivity methods as well as to expose different steps to perform a group study offunctional connectomes.
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Neuronal Networks in Alzheimer's Disease

TL;DR: The literature reviewed here suggests that AD patients are associated with integrative abnormalities in the distributed neuronal networks, which could provide new insights into the disease mechanism in AD and help to uncover an imaging-based biomarker for the diagnosis and monitoring of the disease.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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