The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Journal ArticleDOI
Using joint ICA to link function and structure using MEG and DTI in schizophrenia.
Julia M. Stephen,Brian A. Coffman,Brian A. Coffman,Rex E. Jung,Juan R. Bustillo,Cheryl J. Aine,V.D. Calhoun,V.D. Calhoun +7 more
TL;DR: Results point to dysfunction in a posterior visual processing network in schizophrenia, with reduced MEG amplitude, reduced FA and poorer overall performance on the MATRICS.
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Topological organization of connectivity strength in the rat connectome
TL;DR: The macroscale connectome of the rat brain is analyzed, including detailed information on the macroscale interregional pathways between 67 cortical and subcortical regions as provided by the high-quality, open-access BAMS-II database, showing that pathways with different topological roles have significantly different levels of connectivity strength.
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Cortical Network for Gaze Control in Humans Revealed Using Multimodal MRI
Elaine J. Anderson,Derek K. Jones,Ruth L. O'Gorman,Ruth L. O'Gorman,Alexander Leemans,Marco Catani,Musaid Husain +6 more
TL;DR: Combined fMRI and diffusion MRI–based tractography is used to define the cortical network involved in saccadic eye movement control in humans, demonstrating white matter pathways connecting the frontal eye fields and supplementary eye fields consistent with the known connectivity of these regions in macaque monkeys.
Journal ArticleDOI
Macroscale intrinsic network architecture of the hypothalamus
TL;DR: A novel intrahypothalamic network model is introduced to guide future hypothesis-driven investigations into hypothalamic structure and function and a significant positive correlation between measures of network centrality (dominance) and the inhibitory marker is revealed.
Proceedings ArticleDOI
Multi-view Clustering with Graph Embedding for Connectome Analysis
TL;DR: This paper proposes a Multi-view Clustering framework on graph instances with Graph Embedding (MCGE), which model the multi-view graph data as tensors and apply tensor factorization to learn theMulti-View graph embeddings, thereby capturing the local structure of graphs.
References
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Journal ArticleDOI
Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Dynamic causal modelling.
TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Timothy E.J. Behrens,Heidi Johansen-Berg,Mark W. Woolrich,Mark W. Woolrich,Stephen M. Smith,Claudia A. M. Wheeler-Kingshott,P A Boulby,Gareth J. Barker,E L Sillery,K Sheehan,Olga Ciccarelli,Alan J. Thompson,J. M. Brady,Paul M. Matthews +13 more
TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI
The columnar organization of the neocortex.
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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