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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Structural and functional clusters of complex brain networks

TL;DR: This work investigates synchronization dynamics on the corticocortical network of the cat by modeling each node (cortical area) of the network with a sub-network of interacting excitable neurons and finds that the network displays clustered synchronization behavior, and the dynamical clusters coincide with the topological community structures observed in the anatomical network.
Journal ArticleDOI

Functional Alignment with Anatomical Networks is Associated with Cognitive Flexibility.

TL;DR: In this article, the authors applied emerging tools from graph signal processing to examine whether BOLD signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility.
Proceedings Article

Weight Agnostic Neural Networks

TL;DR: In this paper, the authors propose a search method for neural network architectures that can already perform a task without any explicit weight training. But how important are the weight parameters of a neural network compared to its architecture, they question to what extent neural network architecture alone, without learning any weight parameters, can encode solutions for a given task.
Journal ArticleDOI

Establishing a link between sex-related differences in the structural connectome and behaviour

TL;DR: The results suggest that behavioural sex differences, which indicate complementarity of males and females, are accompanied by related differences in brain structure across development, and that these behavioural and structural patterns correlate with each other, establishing a reliable link between brain and behaviour.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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