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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Graph-based inter-subject pattern analysis of FMRI data.

TL;DR: A novel classification framework based on group-invariant graphical representations is introduced, allowing to overcome the inter-subject variability present in functional magnetic resonance imaging (fMRI) data and to perform multivariate pattern analysis across subjects.
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Accurate prediction of AD patients using cortical thickness networks

TL;DR: This work presents a kernel-based method to establish a network for each subject using mean cortical thickness, which is referred to hereafter as the individual’s network, and uses a nested cross validation framework to choose the optimal hyper-parameters of classifier and evaluate the generalization of the method.
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Abnormal Anatomical Rich-Club Organization and Structural-Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease.

TL;DR: This study found decreased levels of feeder and local connectivity in MCI and AD patients, which were the main contributing factors to the lower efficiency of the brain structural network.
Journal ArticleDOI

Toward a Better Estimation of Functional Brain Network for Mild Cognitive Impairment Identification: A Transfer Learning View

TL;DR: This paper proposes a novel method, namely NERTL (Network Estimation via Regularized Transfer Learning), which first constructs a high-quality network “ template” based on the source data, and then uses the template to guide or constrain the target of FBN estimation by a weighted l1-norm regularizer.
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The thalamic functional gradient and its relationship to structural basis and cognitive relevance.

TL;DR: Overall, the findings suggested that macroscale gradients showed a coordination of structural and functional interactions, with hierarchical organization contributing to behavior characterization.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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