scispace - formally typeset
Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

read more

Content maybe subject to copyright    Report

Citations
More filters
Posted Content

Tensor Regression Networks

TL;DR: This work introduces Tensor Contraction Layers (TCLs) and TRLs, which express outputs through a low-rank multilinear mapping from a high-order activation tensor to an output tensor of arbitrary order, and demonstrates significant performance improvements over comparable architectures on three tasks associated with the UK Biobank dataset.
Journal ArticleDOI

From Functional Architecture to Functional Connectomics

TL;DR: Orientation columns are iconic examples of topographic specificity, whereby axons within a column connect with cells of a single orientation preference, which together with cell-type specificity constitute the major determinants of nonrandom cortical connectivity.
Journal ArticleDOI

Causal networks in simulated neural systems

TL;DR: A series of studies analyzing causal networks in simulated neural systems using a combination of Granger causality analysis and graph theory argue that a causal network perspective may be useful for characterizing the complex neural dynamics underlying consciousness.
Journal ArticleDOI

Brainnetome: A new -ome to understand the brain and its disorders

TL;DR: A brief review on the methodologies of the brainnetome, which include techniques on different scales, the brainnetsome atlas, and methods of brain network analysis, and what actions and measures have been taken to address these challenges in China.
Journal ArticleDOI

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

TL;DR: Together, these findings suggest that the affective dysregulation of BD arises from dynamic instabilities in interoceptive circuits which subsequently impact on fear circuitry and cognitive control systems.
References
More filters
Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
Related Papers (5)