The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Functionally Defined White Matter Reveals Segregated Pathways in Human Ventral Temporal Cortex Associated with Category-Specific Processing
Jesse Gomez,Franco Pestilli,Nathan Witthoft,Golijeh Golarai,Alina Liberman,Sonia Poltoratski,Jennifer M. D. Yoon,Kalanit Grill-Spector +7 more
TL;DR: Measurements of white-matter structure, functional selectivity, and behavior in the same subjects suggest that examining the interplay between cortical function, anatomical connectivity, and visual behavior is integral to understanding functional networks and their role in producing visual abilities and deficits.
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A weighted communicability measure applied to complex brain networks
TL;DR: Experimental results indicate that the initial success of a new weighted network communicability measure in distinguishing local and global differences between diseased patients and controls is able to extract biologically relevant features that are not immediately apparent from the raw connectivity data.
Journal ArticleDOI
The Ontogeny of the Human Connectome Development and Dynamic Changes of Brain Connectivity Across the Life Span
TL;DR: In this article, a review of studies on the cellular and the systems level into macroscopic connectome genesis and dynamics across the life span is presented, showing that in parallel with synaptogenesis, the human connectome formation and transformation is characterized by an initial overgrowth and subsequent elimination of cortico-cortical axonal projections, with an increasingly integrated topology during development, a plateau lasting for the majority of adulthood and an increasingly localized topology in late life.
Journal ArticleDOI
Small-world directed networks in the human brain: multivariate Granger causality analysis of resting-state fMRI.
Wei Liao,Jurong Ding,Daniele Marinazzo,Qiang Xu,Zhengge Wang,Cuiping Yuan,Zhiqiang Zhang,Guangming Lu,Huafu Chen +8 more
TL;DR: The network architecture of the directed influence brain network is revealed using multivariate Granger causality analysis and graph theory on resting-state fMRI recordings and it is suggested that the human brain directed influence network could have a prominent small-world topological property.
Journal ArticleDOI
Characterization of anatomical and functional connectivity in the brain: a complex networks perspective.
TL;DR: Strong evidence is presented that brain networks, ranging from simple nets of interconnected neurons up to macroscopic networks of brain areas display the typical features of complex systems: high clustering, short path lengths, skewed degree distributions, presence of hubs, assortative mixing and the presence of modules.
References
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