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Open AccessJournal ArticleDOI

The Human Connectome: A Structural Description of the Human Brain

TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.
Abstract
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.

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Journal ArticleDOI

Use of resting-state functional MRI to study brain development and injury in neonates.

TL;DR: This review details the evolving understanding of the use of rs-fMRI for studying neonates, and focuses on the biological processes of cortical development related to resting-state network development.
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Multi-Dimensional Dynamics of Human Electromagnetic Brain Activity.

TL;DR: The definition, computation, short history, and pros and cons of connectivity and complex network (graph-theory) analyses applied to MEG/EEG signals applied to source-space connectivity and network analyses are reviewed.
Journal ArticleDOI

A longitudinal study of structural brain network changes with normal aging.

TL;DR: The results of the longitudinal study are consistent with the findings of the previous cross-sectional study: the structural brain networks develop into a fast distribution from young to middle age and eventually became a fast localization in the old age.

In-Vivo Connectivity in Monkeys -- Micro-, Meso- and Macro-Connectomics of the Brain

TL;DR: Nanoconnectomic reconstructions approaching molecular resolution allow us to explore the topology of extracellular space and the precision with which synapses are modified by patterns of neural activity.
Journal ArticleDOI

Computational Architecture of the Parieto-Frontal Network Underlying Cognitive-Motor Control in Monkeys.

TL;DR: The statistical structure of intrinsic parietal and parieto-frontal connectivity in monkeys was studied through hierarchical cluster analysis, which led to five different medio-laterally oriented pillar domains spanning the entire extent of the parietospecific system.
References
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Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Sequence the Human Genome

TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI

Dynamic causal modelling.

TL;DR: As with previous analyses of effective connectivity, the focus is on experimentally induced changes in coupling, but unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic.
Journal ArticleDOI

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging

TL;DR: The results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.
Journal ArticleDOI

The columnar organization of the neocortex.

V B Mountcastle
- 01 Apr 1997 - 
TL;DR: The modular organization of nervous systems is a widely documented principle of design for both vertebrate and invertebrate brains of which the columnar organization of the neocortex is an example.
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