The Human Connectome: A Structural Description of the Human Brain
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TLDR
A research strategy to achieve the connection matrix of the human brain (the human “connectome”) is proposed, and its potential impact is discussed.Abstract:
The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research. However, the network of anatomical connections linking the neuronal elements of the human brain is still largely unknown. While some databases or collations of large-scale anatomical connection patterns exist for other mammalian species, there is currently no connection matrix of the human brain, nor is there a coordinated research effort to collect, archive, and disseminate this important information. We propose a research strategy to achieve this goal, and discuss its potential impact.read more
Citations
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Journal ArticleDOI
Functional and effective connectivity: a review.
TL;DR: The inception of this journal has been foreshadowed by an ever-increasing number of publications on functional connectivity, causal modeling, connectomics, and multivariate analyses of distributed patterns of brain responses.
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Toward discovery science of human brain function
Bharat B. Biswal,Maarten Mennes,Xi-Nian Zuo,Suril Gohel,Clare Kelly,Steve M. Smith,Christian F. Beckmann,Jonathan S. Adelstein,Randy L. Buckner,Stan Colcombe,Anne Marie Dogonowski,Monique Ernst,Damien A. Fair,Michelle Hampson,Matthew J. Hoptman,James S. Hyde,Vesa Kiviniemi,Rolf Kötter,Shi-Jiang Li,Ching Po Lin,Mark J. Lowe,Clare E. Mackay,David J. Madden,Kristoffer Hougaard Madsen,Daniel S. Margulies,Helen S. Mayberg,Katie L. McMahon,Christopher S. Monk,Stewart H. Mostofsky,Bonnie J. Nagel,James J. Pekar,Scott Peltier,Steven E. Petersen,Valentin Riedl,Serge A.R.B. Rombouts,Bart Rypma,Bradley L. Schlaggar,Sein Schmidt,Rachael D. Seidler,Greg J. Siegle,Christian Sorg,Gao Jun Teng,Juha Veijola,Arno Villringer,Martin Walter,Lihong Wang,Xu Chu Weng,Susan Whitfield-Gabrieli,Peter C. Williamson,Christian Windischberger,Yu-Feng Zang,Hong Ying Zhang,F. Xavier Castellanos,F. Xavier Castellanos,Michael P. Milham +54 more
TL;DR: The 1000 Functional Connectomes Project (Fcon_1000) as discussed by the authors is a large-scale collection of functional connectome data from 1,414 volunteers collected independently at 35 international centers.
Journal ArticleDOI
Large-scale brain networks and psychopathology: a unifying triple network model
TL;DR: A triple network model of aberrant saliency mapping and cognitive dysfunction in psychopathology is proposed, emphasizing the surprising parallels that are beginning to emerge across psychiatric and neurological disorders.
Journal ArticleDOI
The economy of brain network organization
Edward T. Bullmore,Olaf Sporns +1 more
TL;DR: It is proposed that brain organization is shaped by an economic trade-off between minimizing costs and allowing the emergence of adaptively valuable topological patterns of anatomical or functional connectivity between multiple neuronal populations.
Journal ArticleDOI
Rich-Club Organization of the Human Connectome
TL;DR: It is demonstrated that brain hubs form a so-called “rich club,” characterized by a tendency for high-degree nodes to be more densely connected among themselves than nodes of a lower degree, providing important information on the higher-level topology of the brain network.
References
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