Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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A historical review and bibliometric analysis of nanoparticles toxicity on algae
TL;DR: In this article, a bibliometric and network analysis of research outputs was carried out to analyze the global research situation and trends of nanoparticles toxicity to algae from 2006 to 2017.
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The applicability of conventional cytotoxicity assays to predict safety/toxicity of mesoporous silica nanoparticles, silver and gold nanoparticles and multi-walled carbon nanotubes.
TL;DR: Conventional cytotoxicity assays are better suited to rank the order of toxicity of different nanoparticles instead of producing accurate IC50 data and using immune cells, especially macrophages together with fibroblasts, would bring more relevant predictions of ENM cytotoxic as immune cells may discover cytot toxicity that is not captured by BALB/c 3T3 cells alone.
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Hazard characterization of silver nanoparticles for human exposure routes.
Yingzhu Li,Enda Cummins +1 more
TL;DR: It was found that AgNP toxicity on traditional major targets of exogenous substances were generally underestimated, and the necessity of the establishment of toxicity tests specifically for nanomaterials is highlighted.
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Enhanced photocatalytic and antibacterial activities of mechanosynthesized TiO2–Ag nanocomposite in wastewater treatment
Moupiya Ghosh,Moumita Mondal,Samir Mandal,Anindita Roy,Subhendu Chakrabarty,Subhendu Chakrabarty,Gopal Chakrabarti,Swapan Kumar Pradhan +7 more
TL;DR: In this paper, a TiO2-Ag nanocomposite (NC) was successfully synthesized by mechanical alloying (MA) for the 3h under Ar atmosphere.
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Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways.
Jing Liu,Yong Zhao,Wei Ge,Pengfei Zhang,Xin-Qi Liu,Wei-Dong Zhang,Yanan Hao,Shuai Yu,Lan Li,Meiqiang Chu,Lingjiang Min,Hongfu Zhang,Wei Shen +12 more
TL;DR: It is suggested that zinc oxide nanoparticles are toxic to the female reproductive system [ovaries (oocytes)] and subsequently embryo-toxic and that precaution should be taken regarding human exposure to their everyday use.
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